I couldn't believe I talked to some idiot the other day who said "since there's no clear-cut evidence that we can be reinfected yet, we should assume you cannot".....that's.....not...how it works.
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 01:36 (three years ago) link
I have a friend who had the virus in April who's gone from "I thought I was dying" to literally not caring about masks, distancing, etc. because he thinks he's immune.
― BRAVE THE AFRIAD (onimo), Monday, 13 July 2020 01:44 (three years ago) link
if antibodies really were that short lived, you'd think we'd have a bunch of examples of people getting reinfected by now right? or do we have to wait until a shithole country like the USA passes the 6-month mark
― frogbs, Monday, 13 July 2020 01:49 (three years ago) link
still hope there is some immunity after infection, even if antibody negative
― Dan S, Monday, 13 July 2020 01:51 (three years ago) link
xpost evidence of re-infection presupposes the person who was infected the first time got tested then tested a second time and a corresponding antibody test, so it's hard to tell with how sloppy the testing is.
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 02:18 (three years ago) link
interesting question might be how many of the people who get reinfected have the same sort of severity the second time around
― frogbs, Monday, 13 July 2020 02:29 (three years ago) link
the Vox article concerned me by mentioning it might be like Dengue Fever, where you can get different strains multiple times, and it's usually worse the second time.
i was freaked out about getting it last Sept-Oct when I was there as I got bit the fuck up by mosquitoes one day.
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 02:43 (three years ago) link
(Philippines = there)
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 02:44 (three years ago) link
viral reinfection so soon doesn't make sense to me, am skeptical
― Dan S, Monday, 13 July 2020 02:59 (three years ago) link
Not my Orange County, but CA.
Nbd just board of education members citing conspiracy theories about harmful nature of masks
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 05:42 (three years ago) link
https://voiceofoc.org/2020/07/oc-board-of-education-considers-schools-returning-with-no-masks-or-distancing/
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 05:43 (three years ago) link
People called me an overreacter when i was upset we were reopening when we did. "It'll be done safely", they said.
Who could have foreseen people going to bars when you reopen them?!
― Donald Trump Also Sucks, Of Course (milo z), Monday, 13 July 2020 06:26 (three years ago) link
symptoms of that Vox patient first time around were “a mild cough and sore throat”there has been plenty of speculation that your infection needs to have been strong enough (no one knows exactly how strong) to provoke a sufficient antibody reaction, otherwise you could get it again. this would seem to fit with that.
― Li'l Brexit (Tracer Hand), Monday, 13 July 2020 07:37 (three years ago) link
https://www.theguardian.com/world/2020/jul/12/immunity-to-covid-19-could-be-lost-in-months-uk-study-suggests
― Pinche Cumbion Bien Loco (stevie), Monday, 13 July 2020 09:21 (three years ago) link
Can't find a link yet but both Dutch and Chinese studies came to the same conclusions in the last couple of days.
― Scampidocio (Le Bateau Ivre), Monday, 13 July 2020 09:27 (three years ago) link
“I cannot underscore how important it is that the public understands that getting infected by this virus is not a good thing. Some of the public, especially the youth, have become somewhat cavalier about getting infected, thinking that they would contribute to herd immunity. Not only will they place themselves at risk, and others, by getting infected, and losing immunity, they may even put themselves at greater risk of more severe lung disease if they get infected again in the years to come.”
But Prof Arne Akbar, an immunologist at UCL, said antibodies are only part of the story. There is growing evidence, he said, that T cells produced to fight common colds can protect people as well. Those patients who fight the virus with T cells may not need to churn out high levels of antibodies, he added.
Shattock said the study was important and indicated that neutralising antibodies rapidly wane. “This certainly suggests that we cannot be confident natural infection will be protective for a significant proportion of individuals, nor certain of the duration of any protection.”
He added: “We would however expect that re-infection would be less severe for any individual as they will still retain immune memory allowing them to more rapidly respond. Nevertheless they could still be a source of onward transmission.
― Matt DC, Monday, 13 July 2020 09:39 (three years ago) link
Well, that's just great. By the way, couldn't help but notice that the Science Editor of the Guardian is called Ian Sample.
― The Fields o' Fat Henry (Tom D.), Monday, 13 July 2020 09:41 (three years ago) link
I presume everyone saw this dead idiot
https://www.theguardian.com/world/2020/jul/13/30-year-old-dies-covid-party-texas
― American Fear of Scampos (Ed), Monday, 13 July 2020 09:41 (three years ago) link
Darwin Awards going to be hotly contested this year
― Pinche Cumbion Bien Loco (stevie), Monday, 13 July 2020 09:55 (three years ago) link
Dead idiot but I can't feel any schadenfreude - there's been a concerted effort of disseminating misinformation ranging from Russia to the GOP to standard issue social media grifters to billionaires who wanted their workers back to downplay the virus. Lot of poor bastards like that guy on their souls.
― Donald Trump Also Sucks, Of Course (milo z), Monday, 13 July 2020 09:59 (three years ago) link
Two nanobodies — small, stable antibody variants derived from llamas — that can neutralize SARS-CoV-2 in cell culture by blocking its interaction with the human ACE2 receptor are reported in a Nature Structural & Molecular Biology paper.Passive immunization, which involves giving a patient virus-neutralizing agents — either serum from people previously infected with SARS-CoV-2 or purified antibodies — could represent a useful therapy for COVID-19. Antibodies against SARS-CoV-1 can neutralize the virus by blocking the binding of the virus’ spike protein to ACE2, but many do not cross-react with SARS-CoV-2. Human antibodies, like those of most mammals, have two chains (heavy and light), but camelids, such as llamas, also possess an additional single heavy chain antibody variant, known as a nanobody. Nanobodies are small, stable and easily produced and thus often serve as alternatives to conventional antibodies for diagnostics and imaging. They are currently being developed against SARS-CoV-2 as research tools and potential therapeutics. James Naismith, Raymond Owens and colleagues report the identification and characterization of two closely related nanobodies (H11-H4 and H11-D4) that can block the attachment of the SARS-CoV-2 spike to ACE2 in cell culture. The nanobodies target a region of the protein immediately adjacent to and slightly overlapping with the ACE2 binding region. Both nanobodies were shown to neutralize live SARS-CoV-2, with H11-H4 showing particularly high potency and additive neutralisation with a human antibody.The authors suggest that the nanobodies may find application alone or in combination with other antibodies used for passive immunization of patients with severe COVID-19. As camelid-derived antibodies are highly conserved with their human counterparts, they are likely to generate only low immune responses against them in humans; nevertheless, well developed humanization strategies are available.
Passive immunization, which involves giving a patient virus-neutralizing agents — either serum from people previously infected with SARS-CoV-2 or purified antibodies — could represent a useful therapy for COVID-19. Antibodies against SARS-CoV-1 can neutralize the virus by blocking the binding of the virus’ spike protein to ACE2, but many do not cross-react with SARS-CoV-2. Human antibodies, like those of most mammals, have two chains (heavy and light), but camelids, such as llamas, also possess an additional single heavy chain antibody variant, known as a nanobody. Nanobodies are small, stable and easily produced and thus often serve as alternatives to conventional antibodies for diagnostics and imaging. They are currently being developed against SARS-CoV-2 as research tools and potential therapeutics. James Naismith, Raymond Owens and colleagues report the identification and characterization of two closely related nanobodies (H11-H4 and H11-D4) that can block the attachment of the SARS-CoV-2 spike to ACE2 in cell culture. The nanobodies target a region of the protein immediately adjacent to and slightly overlapping with the ACE2 binding region. Both nanobodies were shown to neutralize live SARS-CoV-2, with H11-H4 showing particularly high potency and additive neutralisation with a human antibody.
The authors suggest that the nanobodies may find application alone or in combination with other antibodies used for passive immunization of patients with severe COVID-19. As camelid-derived antibodies are highly conserved with their human counterparts, they are likely to generate only low immune responses against them in humans; nevertheless, well developed humanization strategies are available.
https://www.youtube.com/watch?v=GMC3DjAFQEs
― scampo, foggy and clegg (bizarro gazzara), Monday, 13 July 2020 11:05 (three years ago) link
The friendly llamas will save us all!
― Matt DC, Monday, 13 July 2020 11:20 (three years ago) link
there has been plenty of speculation that your infection needs to have been strong enough (no one knows exactly how strong) to provoke a sufficient antibody reaction, otherwise you could get it again. this would seem to fit with that.
Right, but if I were to rephrase this as "Sans a vaccine, this isn't going away until 25% of humanity have serious long term health problems (on top of any they may already have), and 25% of humanity are dead", you can see why my hair might be standing on end?
― Andrew Farrell, Monday, 13 July 2020 11:50 (three years ago) link
on the flip side of this, it'd be good if people could catch and gain immunity to this a bit at a time, if you could arrange that.
― koogs, Monday, 13 July 2020 12:47 (three years ago) link
Btw, saw this bit of mask advice.
There's an infographic version here too about how to wear one, how not to wear one. This is good! pic.twitter.com/oMs4b3dvqc— Daniel Howdon (@danielhowdon) July 13, 2020
― xyzzzz__, Monday, 13 July 2020 12:56 (three years ago) link
I'd missed that the WH is now (finally, inevitably, sadly) attempting to discredit Fauci. We're so fucking fucked.
― Well, that's a fine howdy adieu! (Old Lunch), Monday, 13 July 2020 12:59 (three years ago) link
the only silver lining is that this will hurt him come November even more, but....how happy can I be about that, knowing the cost is tens of thousands of lives?
this is a neverending psychological Hell as much as a physical one
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 13:20 (three years ago) link
xps lol I would hardly call llamas friendly, but yes plz give me their nanobodies
― sleeve, Monday, 13 July 2020 13:51 (three years ago) link
The @voxdotcom article is a perfect example of doing what @BillHanage and I wrote in Feb. would cause trouble with COVID-19: conflating "x is possible" with "x is common." https://t.co/LXkKF6CNYX. Most would expect some reinfections: q is how often, how severe, how contagious? https://t.co/PVCorruQp7— Marc Lipsitch (@mlipsitch) July 13, 2020
― 𝔠𝔞𝔢𝔨 (caek), Monday, 13 July 2020 13:51 (three years ago) link
Got emailed this by my work in anticipation of restarting.
― The Fields o' Fat Henry (Tom D.), Monday, 13 July 2020 13:56 (three years ago) link
Are there any people really unaware of how to wear a mask? I don't think so. People who aren't wearing masks correctly now are doing it because they want to due to discomfort or because they're an asshole.
― akm, Monday, 13 July 2020 17:52 (three years ago) link
Well, there's people who've never worn a mask, for a start.
― The Fields o' Fat Henry (Tom D.), Monday, 13 July 2020 17:55 (three years ago) link
bit strong. don't think a lot of this stuff is overly intuitive
xp
― ||||||||, Monday, 13 July 2020 17:55 (three years ago) link
Is more widespread helpful information a bad thing?
― Mario Meatwagon (Moodles), Monday, 13 July 2020 17:58 (three years ago) link
re: testing availability and delays, i think this TPM post is useful. Also, i wasn't aware of the story behind keisha bottoms' testing, but it seems very instructive on the practical consequences of the delays:
...On its face this may seem simply a matter of frustration and needless anxiety for people waiting for their test results. But it is actually much more than that. Individual patient care is one thing. But at the societal level a core focus of testing is containment and mitigation. The faster you get results the faster you get positive people quarantined and the quicker you can contract trace. If you get a test and then don’t know whether you’re positive for 7 or 10 days you’ve likely infected other people you wouldn’t have if you’d been quarantined. If you’ve quarantined for 10 days when you didn’t have COVID that’s needless disruption for you personally and at scale in the whole society.The Post includes the telling anecdote of the case of Atlanta Mayor Keisha Lance Bottoms. The Bottoms family took precautionary tests after attending a funeral. Tens days later they still hadn’t gotten their results. By then her husband had COVID symptoms. They went for speedier tests at Emory University (possibly available since she’s the Mayor). At that point wife, husband and one son were all positive. Then the original tests came back. Those showed only the son positive.There can be a lag between infection and positivity. So we can’t know for sure. But it seems at least very possible that if the Mayor’s family had gotten their results within a day they would have quarantined their child and neither parent would have been infected at all.The speed of test results is a big, big deal.Put simply, succeeding at mitigation and stamping the virus out (or down to trivial levels) means getting tests back quickly so you can clear those without infections and isolate and contract trace those who are infected. Time is of the essence. If you have these long delays one of the two or three biggest tools for success isn’t even being used.Why is this happening? Once again it seems like the result of a largely absent federal government, no superintending national authority which can oversee and organize the production and distribution of critical supplies, maintain and expand testing capacity beyond state level and more. It’s just not there. As cases mount, of course, the problem will only get worse.
The Post includes the telling anecdote of the case of Atlanta Mayor Keisha Lance Bottoms. The Bottoms family took precautionary tests after attending a funeral. Tens days later they still hadn’t gotten their results. By then her husband had COVID symptoms. They went for speedier tests at Emory University (possibly available since she’s the Mayor). At that point wife, husband and one son were all positive. Then the original tests came back. Those showed only the son positive.
There can be a lag between infection and positivity. So we can’t know for sure. But it seems at least very possible that if the Mayor’s family had gotten their results within a day they would have quarantined their child and neither parent would have been infected at all.
The speed of test results is a big, big deal.
Put simply, succeeding at mitigation and stamping the virus out (or down to trivial levels) means getting tests back quickly so you can clear those without infections and isolate and contract trace those who are infected. Time is of the essence. If you have these long delays one of the two or three biggest tools for success isn’t even being used.
Why is this happening? Once again it seems like the result of a largely absent federal government, no superintending national authority which can oversee and organize the production and distribution of critical supplies, maintain and expand testing capacity beyond state level and more. It’s just not there. As cases mount, of course, the problem will only get worse.
― The GOAT Harold Land (Karl Malone), Monday, 13 July 2020 18:05 (three years ago) link
as I've been around a new roommate this week and had unintentional contact with people, I'm doing an antibody test and two COVID tests spread days apart to rule out false negatives (I'm doing them at places that are free and open so as not to take a slot from someone who is sick).
but yeah, if you aren't quarantining while you wait for test results, that helps nothing. supposed to assume "positive" and live that way until you get "negative"...and even then, right about now, nobody in highly affected areas should be using a negative to do anything cos it's a past data point by that point.
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 18:12 (three years ago) link
in conclusion, everybody in the US will be inside until 2028, by then Liverpool will have won 4 more Premierships, and no American sport will have played a full season
― I hear that sometimes Satan wants to defund police (Neanderthal), Monday, 13 July 2020 18:13 (three years ago) link
Got my negative test result the day after I sent my swab off with the courier.
― kinder, Monday, 13 July 2020 19:48 (three years ago) link
is this real? it's really quite something
Here is a high res version of the Cuomo pandemic poster he unveiled today. pic.twitter.com/3LlcewnuOV— Nick Reisman (@NickReisman) July 13, 2020
― The GOAT Harold Land (Karl Malone), Monday, 13 July 2020 20:37 (three years ago) link
oh it's real
― mookieproof, Monday, 13 July 2020 20:41 (three years ago) link
i rarely saw any of cuomo's briefings, but i tuned in a couple weeks and he was pointing to a big mountain which i think i had a name? i didn't think much of it at the time, but i see there's a whole lexicon here
― The GOAT Harold Land (Karl Malone), Monday, 13 July 2020 20:47 (three years ago) link
How...how is that real? Did someone spill their Mr. Pibb into the simulation server?
― Well, that's a fine howdy adieu! (Old Lunch), Monday, 13 July 2020 20:48 (three years ago) link
honestly i appreciate putting "111 days of hell" right in the middle. the whole thing looks like a tin-poisoned alchemist's lab assistant trying to document a local plague
― The GOAT Harold Land (Karl Malone), Monday, 13 July 2020 20:48 (three years ago) link
but so they're saying the end state is the river/economy falling into the "sea of division"?
― The GOAT Harold Land (Karl Malone), Monday, 13 July 2020 20:49 (three years ago) link
i remain unclear about the boyfriend cliff
― mookieproof, Monday, 13 July 2020 20:52 (three years ago) link
TS: octopus vs. Captain
― Blursday the Vagueteenth of Whenember (Ye Mad Puffin), Monday, 13 July 2020 20:55 (three years ago) link
it's a good to touch to have the dog as the anchor of the tug-of-war team, while trump sits watching on a moon and says "it's just the flu" above
― The GOAT Harold Land (Karl Malone), Monday, 13 July 2020 20:56 (three years ago) link
xp clearly Captain. Captain is anchoring the tug-of-war team, that is the most important position
I love that the artist who worked on previous Weird Cuomo posters is tweeting he didn’t do this.
― Notes on Scampo (tokyo rosemary), Monday, 13 July 2020 21:02 (three years ago) link
Has a little bit of a Crowded House vibe
https://fanart.tv/fanart/music/9854d99f-d954-4c0f-9ae5-58a0cdd885f5/albumcover/the-very-very-best-of-crowded-house-533fdbe647f3e.jpg
http://d24jnm9llkb1ub.cloudfront.net/icpn/00602537703845/00602537703845-cover-zoom.jpg
― Blursday the Vagueteenth of Whenember (Ye Mad Puffin), Monday, 13 July 2020 21:07 (three years ago) link